Inherited canine copper toxicosis in Australian Bedlington Terriers
نویسندگان
چکیده
منابع مشابه
DNA testing for copper toxicosis in Bedlington terriers.
Copper toxicosis is an hereditary disease in which failure of the liver to expel dietary copper leads to a build-up of this toxic metal causing illness and death. It is inherited as an autosomal recessive trait. As such, two copies of the defective gene, one inherited from each parent, need to be present before an individual displays clinical signs. Dogs with one copy of the defective gene and ...
متن کاملAnimal models of copper-associated liver disease
Recent advances in molecular biology have made possible the identification of genetic defects responsible for Wilson's disease, Indian childhood cirrhosis and copper toxicosis in Long Evans Cinnamon rats, toxic milk mice, and Bedlington terriers. The Wilson's disease gene is localized on human chromosome 13 and codes for ATP7B, a copper transporting P-type ATPase. A genetic defect similar to th...
متن کاملIdentification of a new copper metabolism gene by positional cloning in a purebred dog population.
Domesticated animal species such as dogs and cats, with their many different characteristics and breed-specific diseases, and their close relationship and shared environment with humans, are a potentially rich source for the identification of the genetic contribution to human biology and disease. Copper toxicosis in Bedlington terriers is a genetic disease occurring with a high prevalence world...
متن کاملUse of 64copper measurements to diagnose canine copper toxicosis.
Inherited canine copper toxicosis is a serious problem in Bedlington terriers and West Highland White terriers, and may also be a problem in other less-studied breeds. Affected dogs become ill at midlife with progressive and ultimately fatal liver disease. Treatments for removal of copper and prevention of copper accumulation are available, but are most effective if begun before the dog becomes...
متن کاملNew canine models of copper toxicosis: diagnosis, treatment, and genetics.
The One Health principle recognizes that human health, animal health, and environmental health are inextricably linked. An excellent example is the study of naturally occurring copper toxicosis in dogs to help understand human disorders of copper metabolism. Besides the Bedlington terrier, where copper toxicosis is caused by a mutation in the COMMD1 gene, more complex hereditary forms of copper...
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ژورنال
عنوان ژورنال: Journal of Veterinary Science
سال: 2004
ISSN: 1229-845X
DOI: 10.4142/jvs.2004.5.1.19